Valentina Lisitsa is among the most frequently viewed pianists on YouTube. Lisitsa independently launched the beginnings of her career via social media, without initially signing to a tour promoter or record company.

Lisitsa was born in Kiev, Ukraine, in 1973. She started playing the piano at the age of three, performing her first solo recital at the age of four. 

Despite her early disposition to music, her dream at that point was to become a professional chess player. Lisitsa attended the Lysenko music school for Gifted Children and, later, Kiev Conservatory,where she and her future husband, Alexei Kuznetsoff, studied under Dr. Ludmilla Tsvierko. It was when Lisitsa met Kuznetsoff that she began to take music more seriously. In 1991, they won the first prize in The Murray Dranoff Two Piano Competition in Miami, Florida. That same year, they moved to the United States to further their careers as concert pianists. Their New York debut was at the Mostly Mozart Festival at Lincoln Center in 1995.

After the death of her manager, and with the thought that she was "just another blonde Russian pianist," Lisitsa almost gave up on her career as a concert pianist, and contemplated working as a translator for the CIA, but changed her mind at the last minute, influenced by one of her new fans in England. Lisitsa posted her first YouTube video in 2007, gaining even more online attention after uploading her own set of Chopin etudes online for free (in response to an illegal upload of the same set beforehand). Her set of Chopin etudes reached the number one slot on Amazon's classical video recordings, and became the most-viewed online set of Chopin etudes on YouTube.

Furthering her career, Lisitsa and her husband put their life savings in recording a CD of Rachmaninov concertos with the London Symphony Orchestra in 2010. In the spring of 2012, before her Royal Albert Hall debut, Lisitsa was signed on to Decca Records, who later released her Rachmaninov CD set. By mid-2012 she had nearly 50 million views on her YouTube videos.

Lisitsa has performed in various venues around the world, including Carnegie Hall, Avery Fisher Hall, Benaroya Hall, Musikverein and Royal Albert Hall. She is well known for her online recitals and practicing streams. She has also collaborated with violinist Hilary Hahn for various recital engagements.